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KMID : 0829220170410010009
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Korean Journal of Oral and Maxillofacial Pathology
2017 Volume.41 No. 1 p.9 ~ p.16
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Changes in Protein Expression of Oral Cancer Cells Continuosly Exposed to Porphyromonas gingivalis
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Wi Sin-Wook
Woo Vok-Hee
Kim Da-Jeong
Lee Ji-Hye
Park Bong-Soo
Park Hae-Ryoun
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Abstract
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Porphyromonas gingivalis is a gram-negative bacteria of rod shape, and grown in an anerobic condition. It colonizes in subgingival crevice and is known as a major pathogen causing chronic periodontitis. It possesses an invasive property and replicative potential within various cell types, presumably playing an important role in modulating biological behaviors of oral cancer. However, the pathophysiology of P. gingivalis in the malignant transformation of oral cancer has not been fully understood. In this study, we aimed to investigate molecular changes of oral squamous cell carcinoma cells induced by repetitive P. gingivalis infection that clinically resembles chronic periodontitis.
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KEYWORD
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Porphyromonas gingivalis, Oral Cancer, Periodontitis, L-plastin, S1009A
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